SLC7A11 and cancer: Moreover, in 2012, the Cystine/glutamate antiporter xCT (SLC7A11), which modulates the intracellular glutathione levels through regulating cystine-glutamate exchange, was found to exert resistant function on ferroptosis (1), SLC7A11 has been found to be overexpressed in various cancers to rescue the tumor cells from ferroptosis mediated cell death (20, 21).