Therefore, inducing ferroptosis by small molecules (Figures 3, 4) and nanoparticles (Figure 5) to inhibit system Xc− and prevent cystine import, inhibit cystine uptake, directly or covalently inhibit GPX4, to induce the degradation or depletion of GPX4, will provide a novel opportunity for the treatment of various cancers (48). Here, GPX4 is linked to cancer.