Although the perforin-granzyme and the Fas-Fas ligand (FASL) signaling pathway were considered the canonical mechanisms for the function of immunotherapy-induced CD8+ T cells in inducing cancer cell death (12, 13), it was also reported that the CD8+ T cells can inhibit tumor cells through the induction of ferroptosis and pyroptosis (14, 15). This evidence concerns the gene CD8A and cancer.