CD8A and cancer: Furthermore, the effector CD8+ T cells could produce IFNγ to reduce the cancer-associated fibroblasts (CAFs) released cysteine and GSH and subsequently decreased the expression of SLC7A11 and SLC3A2. The cystine uptake was inhibited in cancer cells with low expression of SLC7A11 and SLC3A2 which ultimately triggered the tumor lipid peroxidation and ferroptosis (37).