As previously reported in SCD mice, plasma ET-1 levels were significantly elevated in BERK (325 ± 31 pmol/mL, n=3, p<0.001) and βS-Antilles (211.9 ± 128 pmol/mL, n=3, p<0.01), relative to HbA mice (123 ± 25 pmol/mL, n=3) (23). Here, EDN1 is linked to Schnyder corneal dystrophy.