While variations in IL-1α, IL-1β, IL-10, MnSOD, NFE2L2, CYP2E1, NOS1, NAT2, ABCB1, HFE or MTHFR were not connected to PD risk, we discovered that multiple polymorphisms from IL-6, TNF-α, PON1, CYP2D6, HLA-DRB, BST1, and CCDC62 were statistically correlated with PD risk. The gene discussed is HFE; the disease is Parkinson disease.