In the secondary analysis, by including 2781 PD cases and 3176 controls in DM and RM, PON1 rs854560 variant was positively associated with PD risks (DM: OR[95%CI] =1.21 [1.08-1.35], p=0.0007; RM: OR[95%CI] =1.37[1.15-1.62], p= 0.0003). The gene discussed is PON1; the disease is Parkinson disease.