Regarding genes of cytokine specifically, several studies have noted higher levels of TNF-α, ILs, and other pro-inflammatory cytokines are presented in the peripheral blood, cerebrospinal fluid (CSF) of patients with PD and in the striatum of post-mortem brains from patients with PD (157–159).The inflammatory genes encoding these molecules have also been widely studies, though the results might be inconsistent. Here, TNF is linked to Parkinson disease.