After a combination of quantitative analysis and two-sample MR analysis, we found that TNF-α rs1799964, PON1 rs854560 and CYP2D6 rs3892097 were associated with the higher risk of PD while IL-6 rs1800795, HLA-DRB rs660895, BST1 rs11931532 and CCDC62 rs12817488 were related to the lower risk of PD. This evidence concerns the gene HLA-DRB1 and Parkinson disease.