A previous study reported that quercetin could downregulate IL-6, STAT-3, Bcl2 activity, NF-kB expression, and upregulate the Annexin and the PI cell population through induction of mitochondrial-mediated apoptosis in A549 cells in non-small-cell lung cancer (NSCLC) (96) (Figure 2). The gene discussed is STAT3; the disease is non-small cell lung carcinoma.