Early molecular genetic studies have demonstrated that in the same tumor, both WDCS and the high-grade, noncartilaginous sarcomatous components of DDCS share common genetic alterations in TP53 and copy-number alterations (CNA) at focal chromosomal loci, with the high-grade component displaying additional genomic aberrations such as aneuploidy and more extended CNAs, implying the two components are derived from a single precursor (11). This evidence concerns the gene TP53 and neoplasm.