Further, various variables such as inflammatory biomarkers (e.g., IL-6) and physiological markers (e.g., heart rate variability, heart rate turbulence and temperature variability indices), that were shown to predict mortality in cirrhosis patients (Mani et al., 2009; Bottaro et al., 2020) could be included in the analysis to widen the scope and improve the prognostic value of the parenclitic method. The gene discussed is IL6; the disease is Cirrhosis.