Lately, TAM receptors (TYRO3, AXL, and MERTK), which are tyrosine kinase receptors expressed on monocytes and macrophages and essential for the regulation of immune homeostasis, have been shown to play a central role in cirrhosis and contribute to the systemic immune paresis in patients with cirrhosis and liver failure (Roth lin et al., 2007; Bernsmeier et al., 2015b; Triantafyllou et al., 2018; Brenig et al., 2020; Flint et al., 2022). The gene discussed is TYRO3; the disease is Cirrhosis.