The reduced HLA-DR expression on monocytes in cirrhosis was associated with the expansion of mononuclear myeloid-derived suppressor cells (M-MDSC, CD11b+CD14+HLA-DRlo/−CD15−) (Bronte et al., 2016) in the circulation of patients with cirrhosis (Bernsmeier et al., 2018). The gene discussed is ITGAM; the disease is Cirrhosis.