CD14 and Decreased total monocyte count: In humans, endotoxin induces a rapid yet transient monocytopenia during the first 2 h after lipopolysaccharide (LPS) injection followed by the sequential reappearance of CD14++CD16− classical monocytes, followed by CD14+CD16+ intermediate cells and finally CD14+ CD16++ non-classical monocytes (Thaler et al., 2016; Tak et al., 2017b; Patel et al., 2017).