FGF21 and myocardial infarction: For the subgroup analysis of patients with MI, two studies were included in the analysis (22, 25), and the results showed that higher FGF21 levels were also independently associated with an increased risk of MACE in patients with MI (multivariate HR: 1.82, 95% CI: 1.22–2.71, P < 0.05, I2 = 0%, fixed-effect model; Figure 2B).