Our CUBN aggregate-variant method – which was defined as a genetic risk score (GRS) combining the four variants – showed that a higher number of C-terminal CUBN risk alleles is associated with higher urine albumin and eGFRcreatinine levels and confirms both the single-variant association with higher urine albumin levels reported previously in diabetes and non-diabetes (11, 14), and the consistency of the overall effects on urine albumin levels being greater in diabetes compared to non-diabetes (10, 11). Here, CUBN is linked to diabetes mellitus.