IL6 and chronic kidney disease: In CKD, as cellular senescence occurs, senescent cells lose their ability to grow and repair while secreting SASP components (10, 18), including pro-inflammatory factors such as interleukin-1 (IL-1) and interleukin-6 (IL-6), and pro-fibrotic mediators such as transforming growth factor-β1 (TGF-β1) and matrix metalloproteinases (MMPs).