CKD: Chronic Kidney Disease, COPD: Chronic Obstructive Lung Disease, CHF: Congestive Heart Failure, CAD: Coronary Artery Disease, CVA: Cerebrovascular Accident, SLE: Systemic Lupus Erythematosus, PAD: Peripheral Arterial Disease, HTN: Hypertension, DM: Diabetes Mellitus, TPA: Tissue Plasminogen Activator. The gene discussed is PLAT; the disease is chronic obstructive pulmonary disease.