While the mechanism in which gabapentin is working to reduce SCI-induced autonomic dysreflexia is likely layered, one possible thought is that acute gabapentin treatment is working to prevent the formation of excitatory synapses by blocking TSP (Eroglu et al., 2009) as well as block secretion of intraspinal glutamatergic secretion. Here, THBS1 is linked to autonomic dysreflexia.