Expression of hexokinase (HK1/2), which converts glucose to glucose-6-phosphate, was raised in several pediatric cancers and high HK expression predicted poor prognosis [i.e., metastatic NB (54), the SHH subtype of MB (43), diffuse large B-cell lymphoma (35) and OS (71)]. The gene discussed is HK1; the disease is childhood malignant neoplasm.