AQP4 and myeloid sarcoma: Despite heterogeneous presentation and clinical overlap between MOGAD, multiple sclerosis (MS), and neuromyelitis optica spectrum disease (AQP4-IgG+, NMOSD), distinctive radiologic, pathological, lab, and clinical features of MOGAD have been identified (Table 1), and most recently an international MOGAD diagnostical criteria has been proposed (63).