GALNT6 regulated the pyroptosis of PDAC cells through NF-κB/NLRP3/GSDMD and GSDME signaling (The mechanism diagram is shown in Figure 6I), suggesting that GALNT6 may serve as a novel tumor therapeutic target for PDAC and providing novel insights into the roles of GALNT6 in PDAC progression. Here, GSDME is linked to neoplasm.