DLAT may provide energy for tumor by TCA cycle.DLAT may promote tumor cell proliferation by elevating the level of 6PGD lysine acetylation.The regulation of Sp1-DLAT and eIF4E-DLAT may enhance the proliferation of tumor.DLAT may affect cancer by pyruvate oxidation pathway regulated by E4F1.DLAT may affect cancer regulated by SIRT4. This evidence concerns the gene E4F1 and neoplasm.