DLAT may provide energy for tumor by TCA cycle.DLAT may promote tumor cell proliferation by elevating the level of 6PGD lysine acetylation.The regulation of Sp1-DLAT and eIF4E-DLAT may enhance the proliferation of tumor.DLAT may affect cancer by pyruvate oxidation pathway regulated by E4F1.DLAT may affect cancer regulated by SIRT4. The gene discussed is E4F1; the disease is cancer.