Downregulated expression of LIFR in tumor tissues was seen in ACC (Adrenocortical carcinoma), LAML (Acute Myeloid Leukemia), OV (Ovarian serous cystadenocarcinoma), TGCT (Testicular Germ Cell Tumors), and UCS (Uterine Carcinosarcoma), while there was a significant upregulation in LGG (Brain Lower Grade Glioma) and THYM (Thymoma) (Figure 1B). The gene discussed is LIFR; the disease is central nervous system cancer.