Keywords included (“acupuncture” or “electroacupuncture” or “EA”) and (“NLRP3” or “NLRP3 inflammasome” or “NOD-like receptor protein 3”) and (“stroke” or “vascular dementia” or “Alzheimer’s disease” or “depression” or “spinal cord injury” or “bulbar palsy” or “Parkinson’s disease” or “multiple sclerosis” or “traumatic brain injury” or “” or “brain tumor” or “cerebral palsy” or “headache” or “migraine” or “epilepsy” or “anxiety”). The gene discussed is NLRP3; the disease is depressive disorder.