Keywords included (“acupuncture” or “electroacupuncture” or “EA”) and (“NLRP3” or “NLRP3 inflammasome” or “NOD-like receptor protein 3”) and (“stroke” or “vascular dementia” or “Alzheimer’s disease” or “depression” or “spinal cord injury” or “bulbar palsy” or “Parkinson’s disease” or “multiple sclerosis” or “traumatic brain injury” or “” or “brain tumor” or “cerebral palsy” or “headache” or “migraine” or “epilepsy” or “anxiety”). Here, NLRP3 is linked to early-onset autosomal dominant Alzheimer disease.