NLRP3 and Cognitive impairment: EA may improve the cognitive impairment of APP/PS1 mice by up-regulating the expression of claudin-5 and ZO-1, reducing the transposition of gut-derived lipopolysaccharide (LPS) to the CNS, inhibiting the over-activation of TLR4/NF-κB/NLRP3 pathway, and alleviating the inflammatory reaction of the CNS (Liao et al., 2022).