According to our retrieval strategy, we searched the CNS diseases listed above through the database, and found that acupuncture regulating NLRP3 inflammasome mainly concentrated Alzheimer’s disease, vascular dementia, spinal cord injury, stroke and depression, and only one article about acupuncture treatment of Parkinson’s disease. The gene discussed is NLRP3; the disease is early-onset autosomal dominant Alzheimer disease.