EA at GV20 and GV24 attenuates cognitive impairment by regulating endogenous melatonin secretion through aralkylamine N-acetyltransferase gene synthesis in the pineal gland in MCAO rats and plays neuroprotective effects by upregulating mitophagy-associated proteins and suppressing ROS-induced NLRP3 inflammasome activation after ischemia-reperfusion injury (Zhong et al., 2022). The gene discussed is NLRP3; the disease is Cognitive impairment.