AD organoids also showed greater hyperactivity with Ca2+ firing and were consistent with results reported by Ghatak et al.104Separately, Kuehner et al. showed the influence of DNA 5‐hydroxymethylcytosine (5hmC) levels in normal versus FAD forebrain organoids containing PSEN1 or APP mutations over 112 days.106. The gene discussed is APP; the disease is Alzheimer disease.