Moreover, urate concentration in intestinal has been found to be positively related to sUA, and oral administration of uricase can reduce sUA in hyperuricemic rats and urate oxidase‐deficient mice,19, 21, 29 suggesting that the use of engineered probiotics expressing functional uricase is an attractive strategy for the treatment of hyperuricemia. The gene discussed is UOX; the disease is hyperuricemia.