LTF and central nervous system cancer: The results showed that Lf‐LP‐Mu‐DiR could effectively penetrate across the BBB and blood–brain tumor barrier (BBTB) and then accumulated at glioma site, which were attributed to the Lf targeted recognition effect of Lf‐LP‐Mu‐DiR with LfR on the surface of BBB and gliomas, and muscone modification to promote the BBB permeability, which may be speculated that modified muscone as hydrophobic unit in Lf and muscone dual‐modified liposomes improve the fluidity of phospholipid molecules in the cell membrane,52 increase penetration of modified liposomes into deep tumor tissue.