Several anoikis resistance related signal pathways have been reported in GC, including RhoA pathway, Wnt/β-catenin signaling pathway and EGFR signaling pathway, and these pathways promote angiogenesis, lymph node metastasis and peritoneal metastasis of gastric cancer cells (Wang et al., 2014b; Du et al., 2021; Li et al., 2022). This evidence concerns the gene EGFR and gastric cancer.