Both transgenic mouse models overexpressing the wild‐type (WT) human RTN3 gene (Tg‐RTN3) and Caenorhabditis elegans strain overexpressing the RTN3 homology gene (Tg‐Ret1) presented with overt NAFLD and lipid accumulation. The gene discussed is RTN3; the disease is metabolic dysfunction-associated steatotic liver disease.