IGF2 and chronic kidney disease: Functionally, RTN3 has been found to regulate the activity of Alzheimer's β‐secretase, mediate membrane contact between the ER and plasma membrane by interacting with the cytosolic region of epidermal growth factor receptor, promote lipid synthesis by activating sterol regulatory element‐binding protein 1c (SREBP1c) in adipose tissue, and induce chronic kidney disease via the insulin‐like growth factor 2 (IGF2) pathway.9, 10, 11, 12