Next, to further identify RTN3‐expressing hepatocyte subpopulations, a supervised analysis was performed on a previously published single‐cell RNA sequencing (scRNA‐seq) dataset isolated from the live tissues of chow diet, 15‐ and 30‐week high‐fat high‐fructose diet (HFHFD) mice, in which hepatocyte subpopulations unique to NASH were reported.14 The gene discussed is RTN3; the disease is metabolic dysfunction-associated steatohepatitis.