Our data indicate that at least in CRC cells, Matrin3 knockdown results in increased polymerizing spindle microtubules, delayed mitotic spindle bipolarity, and delayed chromosome congression, possibly leading to reduced cell proliferation, as studies have shown that the stabilization of microtubules inhibit cell proliferation.53–55 Functional studies of human CDC14B protein had conflicting results regarding its role in mitosis. This evidence concerns the gene CDC14B and colorectal carcinoma.