MFGE8 and obesity due to melanocortin 4 receptor deficiency: We have previously shown that MFGE8 promotes the development of obesity both through a direct effect on intestinal fat absorption10 and by reducing gastrointestinal motility, thereby allowing more time for nutrient absorption.27 Furthermore, these effects can be therapeutically targeted independent of each other given that they are mediated by different integrin receptors (αvβ5 for fat absorption and α8β1 for motility effects).