Eighth, HOTAIR affects intracellular formation and transport of tumor-related exosomes via up-regulation of ras-related protein Rab-35 (RAB35), promotes the phosphorylation of synaptosome-associated protein 23 (SNAP23), and induces the translocation of vesicle-associated membrane protein 3 (VAMP3) and SNAP23 to the cytomembrane, and the formation of transmembrane protein soluble N-ethylmaleimide-sensitive fusion factor attachment protein receptor (SNARE), which plays an important role in enhancing the transport of multivesicular bodies (MVBs) related to the formation of exosomes [93]. This evidence concerns the gene HOTAIR and neoplasm.