Multiple negative regulators of YAP identified under physiological conditions, such as cytoplasmic MST1/2[59], LATS1[60], and MST4[56], as well as nuclear factors VGLL4[61] and RUNX3[62], were found to be dramatically reduced or inactivated during GC development, resulting in YAP-dependent GC tumor growth. This evidence concerns the gene MST1 and gastric cancer.