Meanwhile, Timothy Wang’s group found that mice with specific knock-in of nerve growth factor (NGF) in Tff2+ cells (Tff2-Cre;Rosa26NGF+/+) also spontaneously developed metaplasia and dysplasia in the stomach at 8 months, which eventually developed into large gastric tumors with intramucosal adenocarcinoma at 18 months[55]. Here, NGF is linked to gastric neoplasm.