ZP1 and female infertility: The other proteins clustered with the SCMC complex have essential roles in oocyte function: we observe decreased expression of FETUB (a protease inhibitor required for egg fertilization) 28; YBX2, (a major component of the messenger ribonucleoprotein particles (mRNP) whose genetic deletion leads to female infertility) 29; ZP1 (which ensures the structural integrity of the zona pellucida) 30 and NLRP14 (a pivotal regulator in primordial germ cell-like cell differentiation) 31 (Fig. 5A1 and Table S5).