WDR4 and hepatocellular carcinoma: In the same way, the levels of METTL1/WDR4 are increased in hepatocellular carcinoma (HCC) and related to advanced clinical TNM stages and poor overall survival, indicating METTL1/WDR4 mediated m7G tRNA modification enhances the translation of target mRNAs through a codon-frequency-dependent mechanism59.