The loss of METTL1 results in decreased m7G tRNA methylation and expression, inhibition of cell cycle and global translation, as well as the growth of tumors cell in many types, such as melanoma, liposarcoma (LPS), glioblastoma multiforme (GBM), and acute myeloid leukemia (AML). This evidence concerns the gene METTL1 and acute myeloid leukemia.