METTL1 and intrahepatic cholangiocarcinoma: The percentage of G2 phase is increased when METTL1 knockout in mouse embryonic stem cells and intrahepatic cholangiocarcinoma (ICC) cell, lead to slower cell proliferation and colony formation ability is impaired, revealing the key role of METTL1-mediated m7G tRNA modification for the regulation of cell cycle57, 58.