Pathway of neurodegeneration, Amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, Prion disease, Parkinson's disease, Herpes simplex virus 1 infection, Oxidative phosphorylation, Human T-cell leukemia virus 1 infection, and IL-17 signaling pathway showed a close relationship with RalA expression in HSCs. Here, RALA is linked to early-onset autosomal dominant Alzheimer disease.