GCG and early-onset autosomal dominant Alzheimer disease: Pathway enrichment analysis of the top10 up- or downregulated genes in GMP-1 cells (Figure 3F) revealed that Pathway of neurodegeneration, Alzheimer's disease, Huntington's disease, HIF-1 pathway, Prion disease, Parkinson's disease, and Glucagon pathway Glycolysis/Gluconeogenesis were enriched and involved in the RalA-regulated genes in GMPs.