In contrast, blockade of TNFR2 has been shown to induce the death of human OCCAR3 ovarian cancer cells20, and silencing of TNFR2 results in the inhibition of phosphorylation of AKT in HT29 cells9 and inhibits the proliferation of Karpas299 cells19. Here, TNFRSF1B is linked to ovarian carcinoma.