Previous studies also revealed that TNFR2 neutralizing antibody could block the activation of PI3K/AKT and ERK signal pathway in cholangiocarcinoma cells5, and TNFR2 promoted the growth of human SW480, COLO205, and HT29 colorectal cancer cells through PI3K/AKT signaling pathway or activation of STAT39,35. Here, TNFRSF1B is linked to cholangiocarcinoma.