EVs have been found to be involved in the pathogenesis of promoting Aβ formation, transferring tau protein, mediating neuroinflammation, and increasing BBB permeability in elderly patients with SD.167 A series of pre- and clinical studies have shown that some EV-related miRNAs, including miR-188-5p168 and miR-155,169 may be responsible for the pathophysiological process of SD, but none showed reliable specificity. The gene discussed is MAPT; the disease is Salla disease.