Furthermore, in 80 osteosarcoma patients, the mean expressions of p-JAK2 and STAT3 in primary osteosarcoma tissues with lung metastasis (9.23 and 14.82, respectively) are much higher than those without lung metastasis (2.43 and 5.06, respectively), and a positive correlation is evident between both. The gene discussed is STAT3; the disease is osteosarcoma.