VEGFA and osteosarcoma: In human osteosarcoma SJSA and U2OS cells, FLLL32 suppresses cell proliferation more than curcumin and enhances proteasome-mediated degradation of STAT3, resulting in a subsequent loss of vascular endothelial growth factor (VEGF), MMP-2, and survivin expressions, and induction of apoptosis 154 (Table 2).