STAT3 and neoplasm: The diketone analog of curcumin FLLL32, (E)-3-(3,4-dimethoxyphenyl)-1-[1-[(E)-3-(3,4-dimethoxyphenyl)prop2- enoyl] cyclohexyl]prop-2-en-1-one, is a small molecule generated from curcumin using structure-based design and has superior biochemical properties and, more specifically, targets the transcription factor STAT3 for tumor cell proliferation, survival, metastasis, and drug resistance 59, 153.