AKT1 and osteosarcoma: Intriguingly, curcumin-PLGA NP triggers apoptosis of human osteosarcoma U2OS cells through the mitochondria-dependent caspase cascade and the Akt-Bad pathway by up-regulating the expression of cleaved caspases 3 and 9, Bad, cytochrome c, and Apaf-1, as well as down-regulating the expression of p-Akt 182.