Next, in vivo, we created subcutaneous xenograft models of CT26 and consistent with previous findings, knock out of APOL3 promotes CT26 growth in both nude mice and BALB/c mice (Figure 5H), however, with same number of CT26 cells injected, the tumor volume difference was larger in BALB/c mice with normal immune system. The gene discussed is APOL3; the disease is neoplasm.