Third, based on another independent Clinical Proteomic Tumor Analysis Consortium (CPTAC) proteomics CRC data, differential expression analysis (DEA) was performed to determine relative molecules for GPX4 (dataset S3), NOX1 (dataset S4) and ACSL4 (dataset S5), overlapping the statistically significant genes and MEpink modules, APOL3 was screened to be potentially key gene modulating ferroptosis and enhanced tumor infiltrating CD8+ T cells' activity (Figure 1E) and the mRNA differential analysis was shown in Figure S2. The gene discussed is CD8A; the disease is neoplasm.