In a subset of esophageal squamous cell carcinoma (ESCC), interactions between the bromodomain protein BRDT and the △Np63 transcription factor in the SE regions of squamous phenotype-related genes such as KRT14, FAT2, and PTHLH increase their transcription levels, thereby promoting ESCC cell migration 62. Here, FAT2 is linked to esophageal squamous cell carcinoma.