Here, the m6A levels of mRNA were demonstrated to be greatly increased in HCC BM tissues because of the upregulation of the methyltransferase METTL3 and reader YTHDF1. Mechanistically, it was deduced that upregulation of METTL3 stimulates m6A modified ANLN mRNA levels, with YTHDF1 directly binding to m6A sites in ANLN mRNA to maintain ANLN mRNA stability. The gene discussed is YTHDF1; the disease is hepatocellular carcinoma.