Instructively, activation of the KIF2C, MYBL2, HMGB2, and AURKA promoters was enhanced by ANLN overexpression in HCC cells (Fig. 4F & G) while chromatin immunoprecipitation (ChIP)-PCR assays further confirmed the direct binding of ANLN to their respective promoter regions (Supplementary Fig. 5H). Here, HMGB2 is linked to hepatocellular carcinoma.