METTL3 and hepatocellular carcinoma: In addition, DZNeP treatment abolished m6A hypermethylated ANLN and increased ANLN mRNA levels in HCC cells with LV-METTL3 (Supplementary Fig. 7E & F), also diminishing the differences in osteoclast differentiation and BM in vivo between control and METTL3-overexpressing HCC cells (Fig. 6A-E).