In accordance with our study, professor Zhang, as our sincere friend, testified that CTHRC1 participated in the progression of human colorectal cancer as well as gastrointestinal stromal tumors by promoting cancer cell migration and invasion, which was regulated by activating non-canonical WNT-PCP signaling axis but not canonical WNT-β-catenin signaling pathway 61, 62. The gene discussed is CTHRC1; the disease is cancer.