BolA2B has been reported to be involved in the initiation and development of ovarian and liver cancer through its interaction with several metal ion-binding genes, such as GLRX3, GLRX5, and WRNIP1, to activate oxidative phosphorylation, glutathione metabolism, and the proteasomal pathway, leading to cancer progression (Luo et al., 2019; Zhu and Xiao, 2021). The gene discussed is BOLA2B; the disease is liver cancer.