In addition to mediating iron homeostasis, BOLA2 was shown to interact with p62 to activate mTORC1 in transplanted hepatocellular carcinoma (HCC) tumor cells and to stimulate c-MYC oncogenic activity in liver cancer, suggesting that BolA2B may act as a transcription factor regulating additional genetic targets (Hunecke et al., 2012; Luo et al., 2019). This evidence concerns the gene BOLA2 and hepatocellular carcinoma.