Furthermore, our study found the biological function of CD40LG and GZMB might be important for the VAT homeostasis of OSA patients, those two immune-related genes were first reported in the VAT of OSA patients, and their interaction with macrophages and involved pathways might provide new insights for understanding molecular mechanisms of OSA-related metabolic dysregulation. Here, CD40LG is linked to obstructive sleep apnea syndrome.