The levels of CRP, CD40LG, CCL20, GZMB, IL1R1, IL33, and CCL5 in VAT of OSA group were significantly up-regulated, while only the relative mRNA expression of CRP, CD40LG, CCL20 and GZMB were consistent with the bioinformatics analysis results. The gene discussed is IL1R1; the disease is obstructive sleep apnea syndrome.