MTCH2 and acute myeloid leukemia: Furthermore, a study by Khan et al. (2020) has shown that transport of pyruvate into the mitochondria through MTCH2 has been linked to the survival and differentiation of AML leukemia stem cells (LSCs), and inhibition of MTCH2 results in the differentiation of LSCs and reduced survival of cancer cells (de Beauchamp et al., 2022).