While the expression of TRIM27 was consistent across the subtypes, that of ETS1, LEF1, GATA1, and TAL1 was specifically higher in the M6 (starts in very immature forms of red blood cells) and M7 (starts in immature forms of cells that make platelets) AML subtypes (Supplementary Figure S4). Here, TRIM27 is linked to acute myeloid leukemia.