Overall, the upregulation of PDE7B and downregulation of PNMT in the lung tissues of IPF patients identified in our study might conjointly result in decreased β2-AR agonist/cAMP levels, decreased PKA activity, and enhanced glycolysis, which induced excessive collagen production and fibrosis formation. The gene discussed is ADRB2; the disease is idiopathic pulmonary fibrosis.