Moreover, 13.2% (5/38) of fetuses contained variants in COL1A1/COL1A2, 5.3% (2/38) contained variants in PPIB, and one fetus contained variants in PYCR1. These genes were categorized into the group of osteogenesis imperfecta and decreased bone density. Here, PYCR1 is linked to osteogenesis imperfecta.