FGFR3 and achondroplasia: In the present study, 11 cases (Case 13–14, Case 16–18, Case 20–22, Case 24–25, Case 28) had a hotspot mutation, c.1138G>A in FGFR3, that would lead to achondroplasia (MIM_100,800) (Hafner et al., 2006; Natacci et al., 2008).