CD8A and neoplasm: Ex vivo, OT1 mouse CD8+ T lymphocytes were found to increase in proliferation following their co-culture with H-2Kb A9 metastatic tumours treated with SIINKFEKL and cannabigerol or IFN-γ for 48 hours prior to co-culture, suggesting that the OT-1 CD8+ T lymphocytes are activated, which may be expected to result in cytolytic activity against these cells (Figure 5).