NRXN2 and Intellectual disability: Since then, other studies have observed de novo deletions in NRXN2 gene in human patients with ASD, including one missing a chromosomal region spanning the entire NRXN2 gene that was suspected to be associated with the patient’s autistic traits and neurodevelopmental delay (Mohrmann et al., 2011), the other was identified in a patient exhibiting autistic behavior and severe intellectual disability with a 1.6 Mb deletion at the NRXN2 locus (Boyle et al., 2015).