GO functional enrichment analysis revealed that SA regulates biological processes (BP) such as G protein-coupled receptor signaling pathway and blood circulation through cellular calcium homeostasis, adenylate cyclase; molecular functions (MF)such as G protein-coupled peptide receptor activity, peptide binding, and G protein-coupled amine receptor activity; and cellular composition (CC) such as components of the presynaptic membrane, membrane rafts, and the outer side of the plasma membrane for RA. The gene discussed is ADCY1; the disease is rheumatoid arthritis.