FGF9 and rheumatoid arthritis: Sinomenine also has an inhibitory effect on T and B cell activation (Jihong et al., 2005); it also promotes apoptosis of RA-fibroblast-like synoviocytes (FLS) by upregulating the expression of micro RNA-23b-3p and fibroblast growth factor 9 in RA fibroblast-like synoviocytes (Jia et al., 2020).