CASP3 and rheumatoid arthritis: CASP3 is an apoptotic factor (Okamoto et al., 2000), and studies (Wu et al., 2019) have shown that CASP3 is involved in the cell scorching pathway, and that apoptosis and scorching are different ways of programmed necrosis of synovial fibroblasts, ultimately leading to changes in the number of abnormally proliferating synovial fibroblasts and the release of inflammatory factors, which affect the RA process.