TNF and alcohol dependence: Consequently, genistein treatment ameliorated chronic alcohol-induced liver injury, histopathological changes, and lipid peroxidation via inhibition of inflammatory signals such as nuclear factor-κB (NF-κB), monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and transforming growth factor-β1 (TGF-β1) (Zhao et al., 2016).