Indeed, this dynamic may explain why infection induced one canonical YAP target (CTGF) without also inducing another (CYR61); CYR61 is inhibited by the transcriptional repressor FOXO3 and the histone deacetylase HDAC5 (Lee et al., 2007; Tsou et al., 2016), both of which are induced in our bulk RNA-sequencing of Chlamydia-infected End1 cells (FDRP ≤ 0.05, FC: 1.23 and 1.58, respectively). This evidence concerns the gene FOXO3 and infection.