IL17A and periodontitis: demonstrated that berberine increased butyrate production in the intestinal microbiota, effectively restored the intestinal barrier and significantly inhibited IL-17-related systemic and local immune responses in ovariectomized (OVX)-periodontitis rats, resulting in improved periodontal bone resorption (Jia et al., 2019b); moreover, quercetin supplementation was effective in restoring intestinal microbiota, enhancing butyrate production in the gut and significantly improving intestinal ecological dysbiosis in mice treated with antibiotics (Shi et al., 2020), and Mooney et al.