Meanwhile, IF microscopy revealed no significant changes in CD31 expression in tumors (Fig. 4G and H), but significantly fewer CD31+ structures in the OximUNO-treated mice compared with DOX-treated mice (Fig. 4G and I), suggesting that the reduction in nodule number in the OximUNO group (of Fig. 4F) may be mediated by the lower vascularization in the primary tumor. The gene discussed is PECAM1; the disease is neoplasm.