Next, we depleted ezrin using siRNA in MDA-MB-231 and ZR-75-1 breast cancer cells, which have high ezrin levels and exhibit greater resistance to DOX and DTX compared with MCF-7 or T-47D cells and assessed the effect on chemotherapeutic drug sensitivity (see Fig. 2A for ezrin representative immunoblots and quantitation of knockdown levels). This evidence concerns the gene EZR and breast cancer.