Ectopic overexpression of ezrin in MCF-7 and T-47D cells (see Fig. 2A for representative ezrin immunoblots), which exhibited lower endogenous ezrin levels and were highly sensitive to DOX and DTX compared with other breast cancer cells, was associated with 5- to 10-fold increases in IC50 values, indicating increased resistance to DOX or DTX, compared with control cells (empty vector; Table 1). The gene discussed is EZR; the disease is breast carcinoma.