EZR and breast cancer: For instance, multidrug resistance proteins such a P-glycoprotein (P-gp) require ezrin for their proper localization and drug-efflux functions in cancer cells (28, 29); and ezrin is implicated, along with other ERM members, in the transfer of P-gp–mediated drug resistance to previously drug-sensitive breast cancer cells via extracellular vesicles (30, 31).