However, one study showed increased ezrin expression in CHOP (cyclophosphamide, DOX, vincristine, prednisone) resistant diffuse large B-cell lymphoma patient samples; and that downregulating ezrin expression (either directly or by overexpressing miR-148b) attenuated CHOP resistance both in vitro and in vivo (35). Here, DDIT3 is linked to diffuse large B-cell lymphoma.